Pimples vulgaris is the most typical skin disease experienced by doctors, and impacts just about 17 thousand people in the U. s. Declares. Within modern times, several new providers for the therapy of acne have become available. This newspaper provides a brief conversation of the pathophysiology of acne, concepts for effective control, and a summary of current solutions. This is followed by a conversation of the new anti-acne providers and how they fit into a technique for effective therapy of acne.
ACNE, ITS PATHOGENESIS, and the goals of treatment Acne vulgaris is a multifactorial disease, affects the pilosebaceous follicle. It arises from the interplay of 4 pathogenic factors: sebum production, follicular hyperkeratinization, microbial colonization of pilosebaceous units by Propionibacterium acnes, and the release of inflammatory mediators into the follicle and surrounding dermis. Acne begins in the prepubertal period, when increased amounts of adrenal androgens cause enlargement of sebaceous glands and increased production of sebum on the face, chest and back.
Follicular obstruction resulting from the combination of sebum and desquamated epithelial cells results in the formation of a microcomedone, the precursor lesion of acne. This is also a suitable environment for the proliferation of P acnes, an anaerobic diphtheroid that colonizes sebum-rich follicles and uses lipids found in sebum as a nutrient source. Lipase released from P acnes hydrolyze sebum triglycerides into free fatty acids, which irritate the follicular wall and the surrounding dermis after follicular rupture. P acnes also release chemotactic factors and pro-inflammatory mediators that contribute to the inflammatory response observed. The clinical results of these pathophysiological events include noninflammmatory open comedones (blacks points) and closed (pimples), as well as inflammatory papules, pustules and nodules. Although acne is not a fatal disease, has important implications for physical and psychological scars which aspermanent, poor self-image, social inhibition, depression, andanxiety.
STRATEGIES FOR SUCCESS FOR ACNE patient management Management Success factors of acne requires careful evaluation of patients followed by consideration of some "patient factors" and "factors of drugs" in the choice of a particular treatment regimen. Most patients have a mixture of inflammatory and noninflammatory lesions. The predominance of one type, and the number of injuries, plays a role in determining the severity of acne. In addition, other factors to consider are age, skin type (dry, oily, or combination), coexisting conditions, patient motivation, lifestyle, menstrual regularity and premenstrual flareups, evidence of hirsutism, effect of acne, and potential therapies of the patient quality of life. If the patient is taking birth control pills, it is important to determine the brand, as some formulations containing agents (eg, androgenic progestins) that can cause acne.
